Nocturia during steroid therapy.

Nocturia in patients on long-term steroid therapy.

1. About half of our asthmatic patients on long-term treatment with prednisone developed nocturia. 2. This is due to reversal of the normal circadian rhythm of water and electrolyte excretion and is partially corrected within 48 hr of stopping treatment. 3. The disturbance in water and electrolyte excretion appeared to be due to a decrease in proximal tubular reabsorption of sodium at night. Th...

Biloma during steroid therapy for minimal change nephrotic syndrome.

A 27-year-old man, who had been on steroid therapy for 2 months for his nephrotic syndrome, suddenly developed intra-abdominal bile collection (biloma). He had no previous history of abdominal surgery, trauma, or any disease of the hepatobiliary system. The cause of the biloma formation was due, probably, to cholecystitis in the absence of calculi and a pinhole size perforation in the wall of g...

neurobrucellosis and steroid therapy

Pulse steroid therapy.

Intravenous supra-pharmacological doses of corticosteroids are used in various inflammatory and autoimmune conditions because they are cumulatively less toxic than sustained steroid treatment at lower quantitative dosage. Their action is supposed to be mediated through non-genomic actions within the cell. Common indications for use in children include steroid resistant and steroid dependent nep...

Steroid therapy in asthma.

In the following article the indications for the use of steroids in asthma are considered. The risks attendant upon such treatment are discussed. A comparison is made between the effects of the naturally occurring preparations and some of the modern synthetic analogues. The following table shows roughly equivalent doses of the various oral steroid preparations, so that comparable doses can read...